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Prince Frederik of Luxembourg dies from rare disease

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Prince Frederik of Luxembourg, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, has died after a lifelong battle with a rare genetic disorder known as POLG mitochondrial disease. He was 22.

Frederik died in Paris on March 1, his family announced in a statement on the website of the POLG Foundation, which Frederik founded in 2022. “One light was extinguished, but so many remain,” his father said in the statement.

POLG is a “genetic mitochondrial disorder that robs the body’s cells of energy, in turn causing progressive multiple organ dysfunction and failure,” according to the foundation’s website.

Prince Frederik of Luxembourg with his family

Frederik was diagnosed with POLG at age 14, the family said. Because the disease causes such a wide range of symptoms and affects many different organ systems, it can be difficult to diagnose.

The prince died a day after Rare Disease Day, an international day of awareness for rare diseases. An estimated 300 million people live with a rare disease.

“As is the case for 300 million people like Frederik worldwide, these diseases are usually hard to recognise even by physicians, and patients’ families may never know what they are suffering from as they may only be identified very late in their progression,” his father, Robert, said.

There is currently no treatment or cure for POLG.

“One might compare it to having a faulty battery that never fully recharges, is in a constant state of depletion and eventually loses power,” Robert said.

“Frederik and the POLG Foundation … are committed to finding therapies and a cure to save other patients from suffering what Frederik and our family have endured,” he added.

Despite his condition, Frederik “found the strength and the courage to say goodbye to each of us in turn – his brother, Alexander; his sister, Charlotte; me; his three cousins, Charly, Louis, and Donall; his brother-in-law, Mansour; and finally, his Aunt Charlotte and Uncle Mark,” Robert wrote.

“Though Prince Frederik always made it very clear that he did not want the dreadful disease to define him, he devoted himself to spreading awareness on the rare disease,” the family said, including participating in medical trials “with the goal of finding treatments and, perhaps, ways of repurposing molecules to help patients with his condition.”

Frederik’s father, Robert, is a first cousin of the current head of state of Luxembourg, Grand Duke Henri, and is 15th in the line of succession.



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Putin declares brief ‘Easter truce’ in war, but Ukraine says it is still under attack

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Russian President Vladimir Putin declared a brief Easter ceasefire in his war with Ukraine, a declaration met with skepticism in Kyiv as the war enters a crucial phase and US-led negotiations stall.

Putin said “all hostilities” would halt between 6 p.m. Moscow time on Saturday (11 a.m. ET) and midnight on Monday (5 p.m. Sunday ET).

“We assume that the Ukrainian side will follow our example,” he said, adding that the truce would help Russia determine how sincere Kyiv is about wanting to reach a ceasefire.

However, just hours after the announcement, Ukrainian officials accused Russian forces of continuing to fight. “According to the report of the commander-in-chief, Russian assault operations continue in some parts of the frontline and Russian artillery continues to fire,” Ukrainian President Volodymyr Zelensky said in an address on Saturday night.

Kyiv has responded to the truce declaration with skepticism, with Zelensky pointing out that Putin still has not agreed to a US-led proposal for 30 days of ceasefire.

“If Russia is now suddenly ready to actually join the format of complete and unconditional silence, Ukraine will act in a mirror image, as it will on the Russian side. Silence in response to silence, strikes in defense of strikes,” Zelensky said, calling for the Easter truce to be extended to 30 days.

“This will show Russia’s true intentions, because 30 hours is enough for headlines, but not for real confidence-building measures. Thirty days can give peace a chance,” he said.

The timing of the announcement also sparked some questions – coming one day after the Trump administration indicated it was running out of patience with Russia and Ukraine, and just hours after Russia’s Defense Ministry announced its forces had pushed Ukrainian troops from one of their last remaining footholds in Russia’s Kursk region, where the Ukrainians staged a surprise incursion last year.

“Unfortunately, we have had a long history of (Putin’s) statements not matching his actions… Russia can agree at any time to the proposal for a full and unconditional 30-day ceasefire, which has been on the table since March,” Ukraine’s Foreign Minister Andrii Sybiha said on X.

The head of Kherson’s regional military administration, Oleksandr Prokudin, said on Saturday evening local time that a high-rise building in the Dniprovskyi district of Kherson had caught fire after being struck by drones. Russian drones also attacked the villages of Urozhayne and Stanislav, he said.

“Unfortunately, we do not observe any ceasefire. The shelling continues and civilians are under attack again,” Prokudin said. “This is another confirmation that Russia has nothing sacred.”

CNN has reached out to the Russian Ministry of Foreign Affairs for comment.

Air raid sirens sounded in Kyiv and several other regions soon after Putin’s announcement, with the city’s military administration warning of a Russian drone attack. Officials urged people not to leave shelters until the alert was over.

Andrii Kovalenko, who heads the Ukrainian Center for Countering Disinformation, a government body, said on Telegram at 7 p.m. local time that “the Russians continue to fire in all directions.” Moscow and Kyiv are currently on the same time.

Ukrainian troops at three separate locations along the front lines told CNN that as of 8 p.m. Saturday, there was no sign of fighting easing.

There have been no pauses in the conflict since Russia’s launched its unprovoked full-scale invasion in February 2022.

The sudden nature of Putin’s announcement and the short duration of the proposed truce gave Kyiv little room to prepare or maneuver. Many Ukrainian troops participating in ongoing assaults or reconnaissance missions would have been in position already, as any moves are typically made during the night due to the threat from Russian troops.

Ukraine has previously been skeptical about such temporary pauses in conflict, having rejected a temporary ceasefire in January 2023 believing that Russia had ulterior motives in calling for a stop to the fighting, such as using the pause to bring in more troops.

The 2023 truce was similarly announced by Putin to coincide with a holiday – this time with Orthodox Easter, back then with Orthodox Christmas.

Putin’s announcement comes at a pivotal time for the war.

As well as in Kursk, fighting continues along the eastern front line, which has barely moved in the past three years as neither side has been able to make significant gains.

While Ukraine has recently managed to push Russian troops back from areas around Toretsk, Russia has been inching forward near Kupyansk, Lyman and Kurakhove, according to the Institute for the Study of War, a US-based conflict monitor.

Separately, the two sides conducted one of the largest prisoner exchanges of the conflict on Saturday.

According to Zelensky, 277 captured Ukrainian soldiers were returned home. The Russian Defense Ministry said it had swapped 246 captured Ukrainian soldiers for the same number of Russian troops, and that as a “gesture of good will” Russia also exchanged 31 wounded Ukrainian troops for 15 wounded Russian servicemen.

As with previous exchanges, the swap was mediated by the United Arab Emirates.

At the same time, US-led peace efforts are stuttering as Moscow continues to stall, having previously rejected the US proposal for a 30-day ceasefire.

On Friday, US Secretary of State Marco Rubio warned that the US was ready to “move on” within days from efforts to bring peace to Ukraine, if there were no tangible signs of progress.

This is a developing story and will be updated.



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Russia Ukraine truce: The real strategy behind Russia’s sudden truce announcement

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The timing, the brevity, the sudden, unilateral nature of it all. If Ukraine’s allies needed proof of Moscow’s wild cynicism when it comes to peace, the announcement of an immediate truce for Easter provided just that.

It came mere hours after US Secretary of State Marco Rubio, and his boss president Donald Trump said they would need in the coming days an urgent sign that the Kremlin was serious about peace.

For Russia’s proponents, Russian President Vladimir Putin’s announcement on Saturday looked like a nod to Trump – but the sudden declaration is so riddled with practical flaws, before it even gets out of the box, that it is likely to be simply used by Putin to support his false notion Kyiv does not want his war to stop.

It will be a logistical nightmare for Ukraine‘s forces to suddenly, immediately stop fighting at Putin’s behest. Some front line positions may be in the middle of fierce clashes when this order comes through, and a cessation of this nature likely requires days of preparation and readiness.

Misinformation is bound to confuse troops about the truce’s implementation, how to report or respond to violations, and even what to do when it comes to an end.

It is possible this moment will prove a rare sign that both sides can stop violence for short period. But it is significantly more likely they will both use violations and confusion to show their opponent cannot be trusted. As of Saturday evening local time, Ukrainian officials said Russian strikes had continued in frontline areas.

The ongoing 30-day truce limited to energy infrastructure was born in conditions of complete chaos. The White House announced that “energy and infrastructure” were covered, the Kremlin said they’d immediately stopped attacks on “energy infrastructure”, and Ukraine said the truce started a week later than the Kremlin did. Its execution has been equally mired in mistrust and accusations of breaches.

Moscow made a similar unilateral declaration in January 2023, calling for a day of peace to allow Orthodox Christians to observe Christmas – a move that Kyiv and Western leaders dismissed at the time as a strategic pause for military purposes.

A genuine truce requires negotiation with your opponent, and preparations for it to take hold. The sudden rush of this seems designed entirely to placate the White House demands for some sign that Russia is willing to stop fighting. It will likely feed Trump’s at times pro-Moscow framing of the conflict. It may also cause complexities for Ukraine when they are inevitably accused of violating what Washington may consider to be a goodwill gesture by Moscow.

Ultimately, this brief, likely theoretical, probably rhetorical and entirely unilateral stop to a three-year war, is likely to do more damage to the role of diplomacy in the coming months than it does to support it.



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Live updates: Trump news on Iran and Ukraine talks, immigration crackdown, tariffs

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Middle East envoy Steve Witkoff and Iranian Foreign Minister Abbas Araghchi.

Delegations from the United States and Iran are holding their second round of high-stakes nuclear talks today.

Officials from both countries met in Oman last weekend for talks mediated by the Gulf Arab nation. This round is being held in Rome, with Oman once again serving as mediator between the US team — led by special envoy Steve Witkoff — and the Iranian one, headed by Foreign Minister Abbas Araghchi.

How we got here: A nuclear deal was reached in 2015 between Iran and world powers, including the US. Under the deal, Iran had agreed to limit its nuclear program in exchange for the lifting of sanctions.

Trump abandoned that deal in 2018, during his first presidential term. Iran retaliated by resuming its nuclear activities and has so far advanced its program of uranium enrichment up to 60% purity, closer to the roughly 90% level that is weapons grade.

Back in the White House, Trump has given Tehran a two-month deadline to reach a new agreement.

What the US is saying: Trump has vowed a “stronger” deal than the original struck in 2015, and has threatened to bomb Iran if it does not come to an agreement with the US.

Since reporting that last weekend’s initial talks were “constructive,” Trump administration officials oscilated this week between a conciliatory approach and more hawkish demands to fully dismantle Tehran’s nuclear capabilities.

What Iran is saying: Iran this week doubled down on its right to enrich uranium and accused the Trump administration of sending mixed signals.

Iranian media has reported that Tehran had set strict terms ahead of the talks with the US, saying that “red lines” include “threatening language” by the Trump administration and “excessive demands regarding Iran’s nuclear program.”



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